Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

S Rajput; MA Sani; DW Keizer; F Separovic

Journal article

Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides

S Rajput, MA Sani, DW Keizer, F Separovic

Biochemical Society Transactions | PORTLAND PRESS LTD | Published : 2021

DOI: 10.1042/BST20201244

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Abstract

Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ peptide aggregates. The amyloid plaques and soluble oligomeric species of Aβ are believed to be the major cause of synaptic dysfunction in AD brain and their cytotoxic mechanisms have been proposed to involve interactions with cell membranes. In this review, we discuss our solid-state nuclear magnetic resonance (ssNMR) studies of Aβ interactions with model membranes.

University of Melbourne Researchers

Sunnia Rajput Author

Marco Sani Author

David Keizer Author

Frances Separovic Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The authors thank the Australia Research Council for grants DP0984815, DP140102127 and DP190101506. The authors acknowledge support from the Bio21 NMR platform at the University of Melbourne.